Independent research into FGFR3 signalling and targeted inhibition

Biogenesis Labs is a private research laboratory in Cambridge, United Kingdom. We characterise small-molecule kinase inhibitors and study the FGFR3 pathway in preclinical models — all materials are research-grade and handled under laboratory protocol.

Cambridge, UK Founded 2023 FGFR3 · Kinase pathway research Research use only

Research programs

We run a small, focused portfolio of programs. Each is built around careful compound characterisation, dose–response profiling and pathway-level readouts in preclinical systems.

Flagship

FGFR3 signalling & targeted inhibition

Our core program studies the fibroblast growth factor receptor 3 (FGFR3) axis in FGFR3-altered preclinical models. We maintain a curated set of first- and next-generation FGFR inhibitors for comparative potency, selectivity and structure–activity studies, with particular interest in mutant-selective inhibition.

Analytics

Small-molecule characterisation

Every compound entering our programs is fully characterised before use: identity and purity by LC-MS/MS, batch profiling by HPLC, and stability checks under storage conditions. Incoming research materials are verified against supplier certificates of analysis.

Screening

Inhibitor screening & dose–response

We run cell-based and biochemical readouts to profile inhibitor behaviour across concentration series, generating the IC50/EC50 and selectivity data that anchor our comparative studies. Selected preprints are available on request.

Facilities

A compact, fully equipped analytical and cell-biology facility in Cambridge. All work follows internal SOPs; biological materials are handled in a BSL-2 environment.

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Agilent 1260 Infinity II HPLCCompound purity and batch profiling, reversed-phase methods
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SCIEX Triple Quad 7500 LC-MS/MSIdentity confirmation, mass verification, impurity characterisation
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Cell culture suiteBSL-2 certified, HEPA-filtered biosafety cabinets, incubators
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BMF LabCyte plate readerCell-based dose–response and viability assays, multi-well formats
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−80 °C storage & lyophilisationControlled cold chain for research materials, long-term stability storage
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Biochemistry benchReconstitution, dilution series, assay preparation and compound management

Team

A small senior team — most of us work on the bench directly.

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Dr. Julius Hartwell
Principal Investigator

Julius founded Biogenesis Labs and leads the FGFR3 program. PhD in molecular biology with over a decade in targeted pathway research and small-molecule characterisation.

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Dr. Amara Osei
Senior Researcher

Amara runs the cell-based inhibition studies and curates the FGFR3 model panel. Background in receptor tyrosine kinase biology.

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Daniel Marsh
Research Associate — Analytics

Daniel manages incoming-material verification, HPLC/LC-MS method work and batch documentation.

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Priya Nair
Laboratory Technician

Priya supports cell culture, compound preparation and day-to-day facility operations.

Contact

For research material enquiries, collaborations or method-transfer work, get in touch. We respond to all serious enquiries within two working days.

Biogenesis Labs

AddressUnit 4, 12–16 East Road
Cambridge CB1 1AL
United Kingdom
Emailinfo@biogenesislabs.uk
julius.hartwell@biogenesislabs.uk
Phone+44 1223 496 218

Research materials note

All compounds handled by Biogenesis Labs are for laboratory research purposes only and are not for human or veterinary use. Where we source research-grade materials, we require full certificates of analysis and batch documentation prior to acceptance. Purchase orders are issued on laboratory letterhead.